Issue 6, 2008

The oxa-Michael reaction: from recent developments to applications in natural product synthesis

Abstract

In marked contrast to Michael reactions, oxa-Michael reactions have not been used as standard transformations in organic synthesis until quite recently. This was mainly due to a lack of reactivity and selectivity, although the potential products of such reactions are valuable intermediates. This tutorial review presents recent major advances in the field of oxa-Michael (sometimes called oxo-Michael or oxy-Michael) reactions and applications in the total synthesis of complex natural products.

Graphical abstract: The oxa-Michael reaction: from recent developments to applications in natural product synthesis

Article information

Article type
Tutorial Review
Submitted
09 Mar 2008
First published
21 Apr 2008

Chem. Soc. Rev., 2008,37, 1218-1228

The oxa-Michael reaction: from recent developments to applications in natural product synthesis

C. F. Nising and S. Bräse, Chem. Soc. Rev., 2008, 37, 1218 DOI: 10.1039/B718357G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements