Issue 14, 2008

Lewis acid-catalyzed hydrogenation: B(C6F5)3-mediated reduction of imines and nitriles with H2

Abstract

The Lewis acidB(C6F5)3 has been found to be an efficient catalyst for the direct hydrogenation of imines and the reductive ring-opening of aziridines with H2 under mild conditions; addition of a bulky phosphine allows for the reduction of protected nitriles.

Graphical abstract: Lewis acid-catalyzed hydrogenation: B(C6F5)3-mediated reduction of imines and nitriles with H2

Supplementary files

Article information

Article type
Communication
Submitted
03 Dec 2007
Accepted
15 Feb 2008
First published
06 Mar 2008

Chem. Commun., 2008, 1701-1703

Lewis acid-catalyzed hydrogenation: B(C6F5)3-mediated reduction of imines and nitriles with H2

P. A. Chase, T. Jurca and D. W. Stephan, Chem. Commun., 2008, 1701 DOI: 10.1039/B718598G

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