Issue 14, 2008
From the journal:

Organic & Biomolecular Chemistry

Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems†

Christopher A. Hurley,‡a   John B. Wong,a   Jimmy Ho,a   Michele Writer,b   Scott A. Irvine,b   M. Jayne Lawrence,c   Stephen L. Hart,b   Alethea B. Tabora  and  Helen C. Hailes*a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon Street, London, UK
E-mail: h.c.hailes@ucl.ac.uk
Fax: +44 20 7679 7463
Tel: +44 20 7679 4654

b Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, 30 Guilford Street, London, UK

c Pharmaceutical Science Research Division, King's College London, Stamford Street, London, UK

Abstract

A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particular with shorter PEG head groups which may have less effect on peptide targeting in the ternary complex.

Graphical abstract: Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems

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Article information

DOI
https://doi.org/10.1039/B719702K
Article type
Paper
Submitted
20 Dec 2007
Accepted
14 May 2008
First published
30 May 2008

Org. Biomol. Chem., 2008,6, 2554-2559

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Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems

C. A. Hurley, J. B. Wong, J. Ho, M. Writer, S. A. Irvine, M. J. Lawrence, S. L. Hart, A. B. Tabor and H. C. Hailes, Org. Biomol. Chem., 2008, 6, 2554 DOI: 10.1039/B719702K

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