Issue 6, 2008
From the journal:

Molecular BioSystems

Acid cleavable PEG-lipids for applications in a ternary gene delivery vector†‡

John B. Wong,a   Stephanie Grosse,b   Alethea B. Tabor,a   Stephen L. Hartb  and  Helen C. Hailes*a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon Street, London, UK
E-mail: h.c.hailes@ucl.ac.uk
Fax: +44 20 7679 7463
Tel: +44 20 7679 4654

b Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, 30 Guilford Street, London, UK

Abstract

A novel class of pH-sensitive PEG lipids bearing acid-cleavable acetal linkages and short PEG chains have been synthesised and used in ternary vector formulations. The cleavage pH was influenced by structural components including the terminal PEG moiety and spacer length.

Graphical abstract: Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B719782A
Article type
Paper
Submitted
03 Jan 2008
Accepted
27 Mar 2008
First published
15 Apr 2008

Mol. BioSyst., 2008,4, 532-541

Permissions

Request permissions

Acid cleavable PEG-lipids for applications in a ternary gene delivery vector

J. B. Wong, S. Grosse, A. B. Tabor, S. L. Hart and H. C. Hailes, Mol. BioSyst., 2008, 4, 532 DOI: 10.1039/B719782A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements