Issue 8, 2008

Recent advances in enantioselective [2 + 2 + 2] cycloaddition

Abstract

Enantioselective cycloaddition using chiral transition metal catalysts is an atom-economical and efficient synthetic tool for the construction of chiral carbo- and heterocyclic skeletons. This short account discloses our recent results of inter- and intramolecular enantioselective [2 + 2 + 2] cycloadditions of alkyne and/or alkene moiety(ies). Chiral iridium complexes catalyzed the alkyne trimerization for the generation of axial chirality(ies), and chiral rhodium ones catalyzed alkynealkynealkene cyclization for the generation of a quaternary carbon including spirocyclic system.

Graphical abstract: Recent advances in enantioselective [2 + 2 + 2] cycloaddition

Article information

Article type
Emerging Area
Submitted
03 Jan 2008
Accepted
15 Feb 2008
First published
12 Mar 2008

Org. Biomol. Chem., 2008,6, 1317-1323

Recent advances in enantioselective [2 + 2 + 2] cycloaddition

T. Shibata and K. Tsuchikama, Org. Biomol. Chem., 2008, 6, 1317 DOI: 10.1039/B720031E

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