Issue 7, 2008
From the journal:

New Journal of Chemistry

3-Chloromethylpyridyl bipyridinefac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria†‡

Angelo J. Amoroso,a   Richard J. Arthur,a   Michael P. Coogan,*a   Jonathan B. Court,b   Vanesa Fernández-Moreira,a   Anthony J. Hayes,c   David Lloyd,b   Coralie Milletb  and  Simon J. A. Popea  

* Corresponding authors

a Department of Chemistry, Cardiff University, Cardiff, Wales, UK
E-mail: cooganmp@cf.ac.uk
Fax: +44 (0)2920 874030
Tel: +44 (0)2920 874066

b Cardiff School of Biosciences, Main Building, Museum Avenue, Cardiff, Wales, UK

c Confocal Microscopy Unit, Cardiff School of Biosciences, Life Sciences Building, Cardiff, Wales, UK

Abstract

The 3-chloromethylpyridyl bipyridine fac tricarbonyl rhenium cation is a thiol-reactive luminescent agent with a long luminescence lifetime and large Stokes shift that is demonstrated by co-localisation studies to accumulate in mitochondria. This represents the first application of a 3MLCT luminescent agent for the specific targeting of a biological entity in imaging.

Graphical abstract: 3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria

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Article information

DOI
https://doi.org/10.1039/B802215A
Article type
Letter
Submitted
08 Feb 2008
Accepted
18 Apr 2008
First published
23 May 2008

New J. Chem., 2008,32, 1097-1102

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3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria

A. J. Amoroso, R. J. Arthur, M. P. Coogan, J. B. Court, V. Fernández-Moreira, A. J. Hayes, D. Lloyd, C. Millet and S. J. A. Pope, New J. Chem., 2008, 32, 1097 DOI: 10.1039/B802215A

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