Issue 26, 2008
From the journal:

Chemical Communications

Nickel-catalyzed cross-coupling reactions of benzylic zinc reagents with aromatic bromides, chlorides and tosylates†

Matthias A. Schade,a   Albrecht Metzger,a   Stephan Huga  and  Paul Knochel*a  

* Corresponding authors

a Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, Haus F, München, Germany
E-mail: Paul.Knochel@cup.uni-muenchen.de
Fax: (+49)-89-2180-77680
Tel: (+49)-2180-77681

Abstract

Benzylic zinc reagents prepared by direct insertion of zinc to benzylic chlorides in the presence of LiCl undergo smooth cross-coupling reactions with aromatic chlorides, bromides and tosylates using Ni(acac)2 and PPh3 as a catalyst system.

Graphical abstract: Nickel-catalyzed cross-coupling reactions of benzylic zinc reagents with aromatic bromides, chlorides and tosylates

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Article information

DOI
https://doi.org/10.1039/B803072C
Article type
Communication
Submitted
21 Feb 2008
Accepted
11 Mar 2008
First published
24 Apr 2008

Chem. Commun., 2008, 3046-3048

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Nickel-catalyzed cross-coupling reactions of benzylic zinc reagents with aromatic bromides, chlorides and tosylates

M. A. Schade, A. Metzger, S. Hug and P. Knochel, Chem. Commun., 2008, 3046 DOI: 10.1039/B803072C

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