Combination dual responsive polypeptide vectors for enhanced gene delivery

Rujikan Nasanit; Parvez Iqbal; Mahmoud Soliman; Neil Spencer; Stephanie Allen; Martyn C. Davies; Simon S. Briggs; Leonard W. Seymour; Jon A. Preece; Cameron Alexander

doi:10.1039/B803262A

Combination dual responsive polypeptide vectors for enhanced gene delivery†

Rujikan Nasanit,^a Parvez Iqbal,^a Mahmoud Soliman,^b Neil Spencer,^a Stephanie Allen,^b Martyn C. Davies,^b Simon S. Briggs,^c Leonard W. Seymour,*^c Jon A. Preece*^a and Cameron Alexander*^b

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* Corresponding authors

^a School of Chemistry, University of Birmingham, UK
E-mail: j.a.preece@bham.ac.uk
Fax: +44 121 414 4403
Tel: +44 121 414 3528

^b School of Pharmacy, University of Nottingham, Nottingham, UK
E-mail: cameron.alexander@nottingham.ac.uk
Fax: +44 115 951 5102
Tel: +44 115 846 7678

^c Department of Clinical Pharmacology, Old Road Campus Research Building, University of Oxford, Old Road, off Roosevelt Drive, Headington, Oxford, UK
E-mail: len.seymour@clinpharm.ox.ac.uk
Fax: 44+(0)1865 617028
Tel: 44+(0)1865 617040

Abstract

Variation in amino acid sequences on a disulfide-linked polypeptide backbone generates differing pK_a vectors for DNA delivery, which release nucleic acids under reducing conditions and transfect cells with greater efficacy than non-reducible or non-variable pK_a analogues.

Molecular BioSystems

Combination dual responsive polypeptide vectors for enhanced gene delivery†

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Combination dual responsive polypeptide vectors for enhanced gene delivery

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