Issue 28, 2008
From the journal:

Chemical Communications

Reversible siRNA–polymer conjugates by RAFT polymerization†

Karina L. Heredia,ab   Thi H. Nguyen,a   Chien-Wen Chang,a   Volga Bulmus,*bc   Thomas P. Davisb  and  Heather D. Maynard*a  

* Corresponding authors

a Department of Chemistry & Biochemistry and the California NanoSystems Institute, University of California, 607 Charles E. Young Dr. East, Los Angeles, USA
E-mail: maynard@chem.ucla.edu
Tel: +1 310 267 5162

b Centre for Advanced Macromolecular Design, School of Chemical Sciences and Engineering, The University of New South Wales, Sydney, Australia

c School of Biotechnology and Biomolecular Sciences (BABS), The University of New South Wales, Sydney, Australia
E-mail: vbulmus@unsw.edu.au
Tel: +61 2 9385 1199

Abstract

A straightforward synthetic method to prepare pyridyl disulfide end functionalized poly(PEG acrylate) by RAFT polymerization for efficient and reversible conjugation to siRNA is described.

Graphical abstract: Reversible siRNA–polymer conjugates by RAFT polymerization

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Article information

DOI
https://doi.org/10.1039/B804812F
Article type
Communication
Submitted
20 Mar 2008
Accepted
13 May 2008
First published
06 Jun 2008

Chem. Commun., 2008, 3245-3247

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Reversible siRNA–polymer conjugates by RAFT polymerization

K. L. Heredia, T. H. Nguyen, C. Chang, V. Bulmus, T. P. Davis and H. D. Maynard, Chem. Commun., 2008, 3245 DOI: 10.1039/B804812F

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