Issue 30, 2008
From the journal:

Chemical Communications

The effect of 2′-fluorine substitutions on DNA i-motif conformation and stability†

Clare P. Fenna,a   Victoria J. Wilkinson,a   John R. P. Arnold,a   Richard Cosstick*b  and  Julie Fisher*a  

* Corresponding authors

a School of Chemistry, University of Leeds, Leeds, UK
E-mail: j.fisher@chem.leeds.ac.uk
Fax: +44 (0)113 343 6565
Tel: +44 (0)113 343 6577

b Department of Chemistry, University of Liverpool, Crown Street, Liverpool, UK
E-mail: rcosstic@liverpool.ac.uk
Fax: +44 (0)151 794 3588
Tel: +44 (0)151 794 3514

Abstract

1H and 19F NMR, and UV thermal melting studies have established that the stability of d(TCCCCC) is enhanced by the inclusion of a single 2′-fluorine-modified deoxycytidine residue; the results support the notion of the importance of sugar–sugar contacts in stabilising i-motifs in general and reveal that solvation is the cause of the instability of RNA equivalents.

Graphical abstract: The effect of 2′-fluorine substitutions on DNA i-motif conformation and stability

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Article information

DOI
https://doi.org/10.1039/B804833A
Article type
Communication
Submitted
20 Mar 2008
Accepted
29 Apr 2008
First published
05 Jun 2008

Chem. Commun., 2008, 3567-3569

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The effect of 2′-fluorine substitutions on DNA i-motif conformation and stability

C. P. Fenna, V. J. Wilkinson, J. R. P. Arnold, R. Cosstick and J. Fisher, Chem. Commun., 2008, 3567 DOI: 10.1039/B804833A

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