Issue 36, 2008

Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones

Abstract

Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both tri- and difluoromethyl ketones provided excellent levels of stereoinduction (ee 76–99%) under mild reaction conditions and low loading of catalyst (1–5 mol%).

Graphical abstract: Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones

Supplementary files

Article information

Article type
Communication
Submitted
06 May 2008
Accepted
04 Jun 2008
First published
24 Jul 2008

Chem. Commun., 2008, 4360-4362

Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones

M. Bandini, R. Sinisi and A. Umani-Ronchi, Chem. Commun., 2008, 4360 DOI: 10.1039/B807640E

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