Issue 42, 2008
From the journal:

Chemical Communications

Covalent double level dynamic combinatorial libraries: selectively addressable exchange processes†

A. Gastón Orrillo,a   Andrea M. Escalantea  and  Ricardo L. E. Furlan*a  

* Corresponding authors

a Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
E-mail: rfurlan@fbioyf.unr.edu.ar
Fax: +54 (0)3414-375315
Tel: +54 (0)3414-375315

Abstract

Hydrazones and disulfides have been combined in one dynamic system: hydrazones were exchanged by acid catalysis in the presence of disulfide and a thiol group without interference; neutralization of the reaction medium turns off the exchange of hydrazones and, at the same time, activates thiolate–disulfide exchange.

Graphical abstract: Covalent double level dynamic combinatorial libraries: selectively addressable exchange processes

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Article information

DOI
https://doi.org/10.1039/B808565J
Article type
Communication
Submitted
20 May 2008
Accepted
16 Jul 2008
First published
30 Sep 2008

Chem. Commun., 2008, 5298-5300

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Covalent double level dynamic combinatorial libraries: selectively addressable exchange processes

A. G. Orrillo, A. M. Escalante and R. L. E. Furlan, Chem. Commun., 2008, 5298 DOI: 10.1039/B808565J

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