Issue 42, 2008
From the journal:

Chemical Communications

Orthogonal or simultaneous use of disulfide and hydrazone exchange in dynamic covalent chemistry in aqueous solution†

Zaida Rodriguez-Docampoa  and  Sijbren Otto*ab  

* Corresponding authors

a Department of Chemistry, University of Chemistry, Lensfield Road, Cambridge, UK
Fax: +44 1223 336017
Tel: +44 1223 336509

b Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, Groningen, The Netherlands
E-mail: s.otto@rug.nl

Abstract

Hydrazone and disulfide exchange have been combined in a single system, but can be addressed independently: by adjusting the pH of the solution from acidic to mildly basic it is possible to switch from exclusively hydrazone exchange to exclusively disulfide exchange, while at intermediate pH both reactions occur simultaneously.

Graphical abstract: Orthogonal or simultaneous use of disulfide and hydrazone exchange in dynamic covalent chemistry in aqueous solution

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Article information

DOI
https://doi.org/10.1039/B808725C
Article type
Communication
Submitted
22 May 2008
Accepted
16 Jul 2008
First published
11 Sep 2008

Chem. Commun., 2008, 5301-5303

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Orthogonal or simultaneous use of disulfide and hydrazone exchange in dynamic covalent chemistry in aqueous solution

Z. Rodriguez-Docampo and S. Otto, Chem. Commun., 2008, 5301 DOI: 10.1039/B808725C

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