Issue 12, 2008

Chiral HPLC for efficient resolution of enantiomers

Abstract

Resolution of racemic compounds is one of the potential ways of obtaining both enantiomers. Among several resolution techniques in the past few decades, direct enantioseparation by high-performance liquid chromatography (HPLC) has significantly advanced, and a large number of chiral stationary phases (CSPs) for HPLC have been developed using both chiral small molecules and polymers with chiral recognition abilities. In this tutorial review, after describing the brief history and general view of CSPs, special emphasis will be placed on the studies involving the development and application of polysaccharide-based CSPs in our group.

Graphical abstract: Chiral HPLC for efficient resolution of enantiomers

Article information

Article type
Tutorial Review
Submitted
29 Jul 2008
First published
29 Sep 2008

Chem. Soc. Rev., 2008,37, 2593-2608

Chiral HPLC for efficient resolution of enantiomers

Y. Okamoto and T. Ikai, Chem. Soc. Rev., 2008, 37, 2593 DOI: 10.1039/B808881K

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