Issue 36, 2008
From the journal:

Chemical Communications

Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence†

Craig P. Montgomery,a   Elizabeth J. New,a   David Parker*a  and  Robert D. Peacockb  

* Corresponding authors

a Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: david.parker@durham.ac.uk

b Department of Chemistry, Glasgow University, Glasgow, UK

Abstract

The helicity of the (SSS)-Δ enantiomer of a terbium and europium(III) complex is inverted on reversible binding to ‘drug site II’ of serum albumin, signalled by a switch in its circularly polarised emission; no such behaviour occurs with the (RRR)-Λ complexes, thereby defining a unique chiroptical probe of albumin binding.

Graphical abstract: Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

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Article information

DOI
https://doi.org/10.1039/B810978H
Article type
Communication
Submitted
27 Jun 2008
Accepted
15 Jul 2008
First published
10 Sep 2008

Chem. Commun., 2008, 4261-4263

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Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence

C. P. Montgomery, E. J. New, D. Parker and R. D. Peacock, Chem. Commun., 2008, 4261 DOI: 10.1039/B810978H

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