Issue 35, 2008
From the journal:

Chemical Communications

Dynamic resolution of N-Boc-2-lithiopiperidine†

Iain Coldham,*a   Sophie Raimbault,a   Praful T. Chovatia,a   Jignesh J. Patel,a   Daniele Leonori,a   Nadeem S. Sheikha  and  David T. E. Whittakerb  

* Corresponding authors

a Department of Chemistry, University of Sheffield, Sheffield, UK
E-mail: i.coldham@sheffield.ac.uk
Fax: (+44) 114 222 9346
Tel: (+44) 114 222 9428

b AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, UK

Abstract

Dynamic thermodynamic resolution of N-Boc-2-lithiopiperidine is possible using a chiral ligand; the two enantiomers of this organolithium can be resolved with selectivities of up to 85 : 15 from a selection of 26 chiral diamino-alkoxide ligands screened.

Graphical abstract: Dynamic resolution of N-Boc-2-lithiopiperidine

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B810988E
Article type
Communication
Submitted
27 Jun 2008
Accepted
29 Jul 2008
First published
08 Aug 2008

Chem. Commun., 2008, 4174-4176

Permissions

Request permissions

Dynamic resolution of N-Boc-2-lithiopiperidine

I. Coldham, S. Raimbault, P. T. Chovatia, J. J. Patel, D. Leonori, N. S. Sheikh and D. T. E. Whittaker, Chem. Commun., 2008, 4174 DOI: 10.1039/B810988E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements