Issue 12, 2008

Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters

Abstract

This paper presents the development of an easy-to-handle and disposable clinical diagnostic lab-on-a-chip using fully integrated plastic microfluidic components, which has the sampling/identifying capability to make fast and reliable measurements of metabolic parameters from human whole blood. A smart and functional lab-on-a-chip cartridge, which incorporates a full on-chip auto-calibration function for in the field applications, has been developed, and then fully characterized using a portable analyzer (3 ¼″ × 5″ × 1″) with multi-analyte detection capability. In addition, several new approaches in realizing smart and functional lab-on-a-chips on polymer have been adopted, which include the pinch valve for automatic fluidic sealing, a by-pass channel as the sampling indicator, and a robust connector design for long analyzer lifetimes. Metabolic parameters such as glucose, lactate, and partial oxygen from human whole blood have been successfully measured using the functional polymer lab-on-a-chips and the portable analyzer developed in this work.

Graphical abstract: Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters

Article information

Article type
Paper
Submitted
02 Jul 2008
Accepted
17 Sep 2008
First published
23 Oct 2008

Lab Chip, 2008,8, 2113-2120

Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters

J. Do, S. Lee, J. Han, J. Kai, C. Hong, C. Gao, J. H. Nevin, G. Beaucage and C. H. Ahn, Lab Chip, 2008, 8, 2113 DOI: 10.1039/B811169C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements