Issue 23, 2008
From the journal:

Organic & Biomolecular Chemistry

Enzymes containing porous polymersomes as nano reaction vessels for cascade reactions

Suzanne M. Kuiper,a   Madhavan Nallani,a   Dennis M. Vriezema,a   Jeroen J. L. M. Cornelissen,a   Jan C. M. van Hest,a   Roeland J. M. Noltea  and  Alan E. Rowan*a  

* Corresponding authors

a Molecular Materials, Institute for Molecules and Materials, University of Nijmegen, Toernooiveld 1, Nijmegen, Gelderland, Netherlands

Abstract

Polystyrene40-b-poly(isocyanoalanine(2-thiophen-3-yl-ethyl)amide)50 (PS-PIAT) polymersomes have the unique property of being sufficiently porous to allow diffusion of small (organic) substrates while retaining large biomolecules such as enzymes inside. Herein we report on the encapsulation and protection of glucose oxidase (GOx) and horse radish peroxidase (HRP) in PS-PIAT polymersomes and the successful employment of these functionalised nanoreactors in a cascade reaction. The demonstrated concept allows for further application in other enzymatic cascade reactions, bio-organic hybrid systems and biosensing devices.

Graphical abstract: Enzymes containing porous polymersomes as nano reaction vessels for cascade reactions

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Article information

DOI
https://doi.org/10.1039/B811196K
Article type
Paper
Submitted
03 Jul 2008
Accepted
28 Aug 2008
First published
15 Oct 2008

Org. Biomol. Chem., 2008,6, 4315-4318

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Enzymes containing porous polymersomes as nano reaction vessels for cascade reactions

S. M. Kuiper, M. Nallani, D. M. Vriezema, J. J. L. M. Cornelissen, J. C. M. van Hest, R. J. M. Nolte and A. E. Rowan, Org. Biomol. Chem., 2008, 6, 4315 DOI: 10.1039/B811196K

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