Issue 39, 2008

Synergistic effects in gene delivery—a structure–activity approach to the optimisation of hybrid dendritic–lipidic transfection agents

Abstract

Novel gene delivery agents based on combining cholesterol units with spermine-functionalised dendrons exhibit enhanced transfection ability—we report significant synergistic effects in mixed (hybrid) systems which combine aspects of both main classes of synthetic vectors, i.e., cationic polymers and lipids.

Graphical abstract: Synergistic effects in gene delivery—a structure–activity approach to the optimisation of hybrid dendritic–lipidic transfection agents

Supplementary files

Article information

Article type
Communication
Submitted
10 Jul 2008
Accepted
13 Aug 2008
First published
03 Sep 2008

Chem. Commun., 2008, 4700-4702

Synergistic effects in gene delivery—a structure–activity approach to the optimisation of hybrid dendritic–lipidic transfection agents

S. P. Jones, N. P. Gabrielson, D. W. Pack and D. K. Smith, Chem. Commun., 2008, 4700 DOI: 10.1039/B811852C

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