Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by PdCl2

Shengqing Ye; Qiuping Ding; Zhiyong Wang; Haibo Zhou; Jie Wu

doi:10.1039/B812015C

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by PdCl₂†‡

Shengqing Ye,^a Qiuping Ding,^a Zhiyong Wang,^a Haibo Zhou^a and Jie Wu*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, China
E-mail: jie_wu@fudan.edu.cn
Fax: 86 21 6510 2412
Tel: 86 21 5566 4619

^b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China

Abstract

Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by palladium chloride are described. This reaction is performed in the presence of 10 mol% of palladium chloride in THF at 80 °C, which provides an efficient and practical route for the synthesis of 1,2-disubstituted indoles.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/B812015C
Article type: Paper
Submitted: 14 Jul 2008
Accepted: 01 Sep 2008
First published: 15 Oct 2008

Download Citation

Org. Biomol. Chem., 2008,6, 4406-4412

Permissions

Request permissions

Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isocyanates catalyzed by PdCl₂

S. Ye, Q. Ding, Z. Wang, H. Zhou and J. Wu, Org. Biomol. Chem., 2008, 6, 4406 DOI: 10.1039/B812015C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry