A modular and organocatalytic approach to γ-butyrolactone autoregulators from Streptomycetes†
Abstract
A general synthesis of optically active γ-butyrolactone autoregulators is developed by a two-step sequence to assemble 2,3-trans-disubstituted butyrolactones in high yields and enantioselectivities; the scope of this reaction was elaborated by setting up a library of