Issue 45, 2008
From the journal:

Chemical Communications

A new bio-active surface for protein immobilisation viacopper-free ‘click’ between azido SAM and alkynyl Fischer carbene complex†

Sudeshna Sawoo,a   Piyali Dutta,a   Amarnath Chakraborty,a   Rupa Mukhopadhyay,b   Othman Bouloussac  and  Amitabha Sarkar*a  

* Corresponding authors

a Department of Organic Chemistry, Indian Association for the Cultivation of Science, Kolkata-700032, India
E-mail: ocas@iacs.res.in
Fax: +91332473280
Tel: +913324734971

b Department of Biological Chemistry, Indian Association for the Cultivation of Science, Kolkata-700032, India

c Institut Curie, Laboratoire Physico-Chimie Curie (UMR CNRS 168), 26 rue d'Ulm, 75248 Paris cedex 05, France

Abstract

Fischer carbene complex anchored on glass or silicon surface using a Cu-free ‘click’ reaction allows facile and swift covalent grafting of protein molecules like Bovine Serum Albumin (BSA).

Graphical abstract: A new bio-active surface for protein immobilisation viacopper-free ‘click’ between azido SAM and alkynyl Fischer carbene complex

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Article information

DOI
https://doi.org/10.1039/B813296H
Article type
Communication
Submitted
31 Jul 2008
Accepted
19 Sep 2008
First published
09 Oct 2008

Chem. Commun., 2008, 5957-5959

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A new bio-active surface for protein immobilisation viacopper-free ‘click’ between azido SAM and alkynyl Fischer carbene complex

S. Sawoo, P. Dutta, A. Chakraborty, R. Mukhopadhyay, O. Bouloussa and A. Sarkar, Chem. Commun., 2008, 5957 DOI: 10.1039/B813296H

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