Issue 7, 2009
From the journal:

Lab on a Chip

Microfluidic assisted synthesis of multi-functional polycaprolactone microcapsules: incorporation of CdTe quantum dots, Fe3O4 superparamagnetic nanoparticles and tamoxifen anticancer drugs†

C.-H. Yang,*a   K.-S. Huang,b   Y.-S. Lin,c   K. Lu,d   C.-C. Tzeng,e   E.-C. Wang,e   C.-H. Lin,f   W.-Y. Hsua  and  J.-Y. Changg  

* Corresponding authors

a Dept. of Biological Science & Technology, I-Shou University, Taiwan
E-mail: chyang@isu.edu.tw
Fax: +886-7-615-1959
Tel: +886-7-615-1100 ext. 7312

b Dept. of Biomedical Engineering, I-Shou University, Taiwan

c Instrument Technology Research Center, National Applied Research Laboratories, Taiwan

d Dept. of Physical Therapy, I-Shou University, Taiwan

e Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Taiwan

f Dept. of Mechanical and Electro-Mechanical Engineering, National Sun Yat-Sen University, Taiwan

g Nanopowder and Thin Film Technology Center, Industrial Technology Research Institute, Taiwan

Abstract

This paper demonstrates a proof-of-concept approach for encapsulating the anticancer drug tamoxifen, Fe3O4nanoparticles (NPs) and CdTe quantum dots (QDs) into size-controlled polycaprolactone (PCL) microcapsules utilizing microfluidic emulsification, which combined magnetic targeting, fluorescence imaging and drug controlled release properties into one drug delivery system. Cross-linking the composite PCL microcapsules with poly(vinyl alcohol) (PVA) tailored their size, morphology, optical and magnetic properties and drug release behaviors. The flow conditions of the two immiscible solutions were adjusted in order to successfully generate various sizes of polymer droplets. The result showed superparamagnetic and fluorescent properties, and was used as a controlled drug release vehicle. The composite magnetic and fluorescent PCL microcapsules are potential candidates for a smart drug delivery system.

Graphical abstract: Microfluidic assisted synthesis of multi-functional polycaprolactone microcapsules: incorporation of CdTe quantum dots, Fe3O4 superparamagnetic nanoparticles and tamoxifen anticancer drugs

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Article information

DOI
https://doi.org/10.1039/B814952F
Article type
Paper
Submitted
27 Aug 2008
Accepted
24 Nov 2008
First published
19 Dec 2008

Lab Chip, 2009,9, 961-965

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Microfluidic assisted synthesis of multi-functional polycaprolactone microcapsules: incorporation of CdTe quantum dots, Fe3O4 superparamagnetic nanoparticles and tamoxifen anticancer drugs

C.-H. Yang, K.-S. Huang, Y.-S. Lin, K. Lu, C.-C. Tzeng, E.-C. Wang, C.-H. Lin, W.-Y. Hsu and J.-Y. Chang, Lab Chip, 2009, 9, 961 DOI: 10.1039/B814952F

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