Issue 4, 2009
From the journal:

Chemical Communications

3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters†

Jaskiranjit Kang,a   Jonathan P. Richardsona  and  Derek Macmillan*a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon Street, London, UK
E-mail: d.macmillan@ucl.ac.uk
Tel: 020-7679 4684

Abstract

Peptides and proteins fragment sequence-specifically in the presence of 3-mercaptopropionic acid to afford thioesters which can be used in native chemical ligation reactions.

Graphical abstract: 3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters

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Article information

DOI
https://doi.org/10.1039/B815888F
Article type
Communication
Submitted
10 Sep 2008
Accepted
10 Oct 2008
First published
05 Nov 2008
This article is Open Access

Chem. Commun., 2009, 407-409

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3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters

J. Kang, J. P. Richardson and D. Macmillan, Chem. Commun., 2009, 407 DOI: 10.1039/B815888F

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