Issue 4, 2009

Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

Abstract

Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence of fluorotyrosine may result in an improvement of the biological properties of this lipopeptide. The fluorinated iturin might also be used as a probe for studying its interaction with biological membranes.

Graphical abstract: Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

Supplementary files

Article information

Article type
Communication
Submitted
18 Sep 2008
Accepted
22 Dec 2008
First published
08 Jan 2009

Org. Biomol. Chem., 2009,7, 644-646

Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.

S. Moran, D. K. Rai, B. R. Clark and C. D. Murphy, Org. Biomol. Chem., 2009, 7, 644 DOI: 10.1039/B816345F

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