Issue 3, 2009

Reversible molecular switching of molecular beacon: controlling DNA hybridization kinetics and thermodynamics using mercury(ii) ions

Abstract

We report that the hydrogen-bonding pattern in a molecular beacon can be replaced by metal-dependent pairs of Hg2+ and DNA thymine (T) bases. A molecular beacon based on T–Hg2+–T exhibits a lower background signal and higher thermostability than regular molecular beacons.

Graphical abstract: Reversible molecular switching of molecular beacon: controlling DNA hybridization kinetics and thermodynamics using mercury(ii) ions

Supplementary files

Article information

Article type
Communication
Submitted
23 Sep 2008
Accepted
30 Oct 2008
First published
20 Nov 2008

Chem. Commun., 2009, 322-324

Reversible molecular switching of molecular beacon: controlling DNA hybridization kinetics and thermodynamics using mercury(II) ions

R. Yang, J. Jin, L. Long, Y. Wang, H. Wang and W. Tan, Chem. Commun., 2009, 322 DOI: 10.1039/B816638B

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