Issue 4, 2009

Recent advances in enantioselective copper-catalyzed 1,4-addition

Abstract

A comprehensive overview of recent literature from 2003 concerning advances in enantioselective copper catalysed 1,4-addition of organometallic reagents to α,β-unsaturated compounds is given in this critical review. About 200 ligands and catalysts are presented, with a focus on stereoselectivities, catalyst loading, ligand structure and substrate scope. A major part is devoted to trapping and tandem reactions and a variety of recent synthetic applications are used to illustrate the practicality and current state of the art of 1,4-addition of organometallic reagents. Finally several mechanistic studies are discussed (162 references).

Graphical abstract: Recent advances in enantioselective copper-catalyzed 1,4-addition

Article information

Article type
Critical Review
Submitted
25 Sep 2008
First published
11 Feb 2009

Chem. Soc. Rev., 2009,38, 1039-1075

Recent advances in enantioselective copper-catalyzed 1,4-addition

T. Jerphagnon, M. G. Pizzuti, A. J. Minnaard and B. L. Feringa, Chem. Soc. Rev., 2009, 38, 1039 DOI: 10.1039/B816853A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements