Issue 5, 2009
From the journal:

Soft Matter

Rapidly in situ forming hydrophobically-modified chitosan hydrogels via pH-responsive nanostructure transformation†

Ya-Ling Chiu,a   Mei-Chin Chen,a   Chun-Yu Chen,a   Po-Wei Lee,a   Fwu-Long Mi,b   U-Ser Jeng,c   Hsin-Lung Chen‡*a  and  Hsing-Wen Sung‡*a  

* Corresponding authors

a Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, R.O.C
E-mail: hlchen@che.nth.edu.tw, hwsung@che.nthu.edu.tw
Fax: +886-3-573-8415
Tel: +886-3-572-1714

b Department of Biotechnology, Vanung University, Chungli, Taiwan, R.O.C

c National Synchrotron Radiation Research Center (NSRRC), Hsinchu, Taiwan, R.O.C

Abstract

A pH-responsive hydrogel targeted for various biomedical applications has been developed using a naturally-abundant biopolymer, chitosan, with controlled grafting of hydrophobic side chains. The rapid hydrogelation is driven by a transformation of the nanostructure of the side-chain aggregates from local micelles to interconnected nanodomains in a sponge phase due to the dominance of hydrophobic interaction near physiological pH.

Graphical abstract: Rapidly in situ forming hydrophobically-modified chitosan hydrogels via pH-responsive nanostructure transformation

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Article information

DOI
https://doi.org/10.1039/B818906D
Article type
Communication
Submitted
24 Oct 2008
Accepted
05 Jan 2009
First published
22 Jan 2009

Soft Matter, 2009,5, 962-965

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Rapidly in situ forming hydrophobically-modified chitosan hydrogels via pH-responsive nanostructure transformation

Y. Chiu, M. Chen, C. Chen, P. Lee, F. Mi, U. Jeng, H. Chen and H. Sung, Soft Matter, 2009, 5, 962 DOI: 10.1039/B818906D

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