3S-Fluoroproline as a probe to monitor proline isomerization during protein folding by 19F-NMR

Colin A. Thomas; Erach R. Talaty; James G. Bann

doi:10.1039/B821952D

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3S-Fluoroproline as a probe to monitor proline isomerization during protein folding by ¹⁹F-NMR†

Colin A. Thomas,^ab Erach R. Talaty^a and James G. Bann*^a

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* Corresponding authors

^a Department of Chemistry, Wichita State University, Wichita, KS 67260-0051, USA
E-mail: jim.bann@wichita.edu
Fax: +1 316-978-3431
Tel: +1 316-978-7373

^b Department of Chemistry, Carroll College, 1601 N Benton Ave., Helena, USA

Abstract

Variable-temperature inversion transfer NMR is used to determine the kinetic and thermodynamic parameters of cis–transisomerization of N-Ac-(3R) and (3S)-fluoroproline-OMe.

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Supplementary files

¹⁹F-NMR spectra of 1 and 2 at 35 °C in 90% H₂O/10% D₂O, synthesis of (3S)-fluoro-L-proline and N-acetyl-(3S)-3-fluoro-L-proline methyl ester, and determination of thekinetic and thermodynamic parameters PDF (345K)

Article information

DOI: https://doi.org/10.1039/B821952D
Article type: Communication
Submitted: 08 Dec 2008
Accepted: 29 Apr 2009
First published: 19 May 2009

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Chem. Commun., 2009, 3366-3368

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3S-Fluoroproline as a probe to monitor proline isomerization during protein folding by ¹⁹F-NMR

C. A. Thomas, E. R. Talaty and J. G. Bann, Chem. Commun., 2009, 3366 DOI: 10.1039/B821952D

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