Issue 15, 2009
From the journal:

Chemical Communications

Asymmetric generation of fluorine-containing quaternary carbons adjacent to tertiary stereocenters: uses of fluorinated methines as nucleophiles†

Xiao Han,a   Jie Luo,a   Chen Liuab  and  Yixin Lu*ab  

* Corresponding authors

a Department of Chemistry, National University of Singapore, Singapore, Republic of Singapore
E-mail: chmlyx@nus.edu.sg
Fax: +65-6779-1691
Tel: +65-6516-1569

b Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore

Abstract

Organocatalytic asymmetric Michael reactions of fluorinated nucleophiles with nitroolefins catalyzed by Cinchona alkaloid-derived thioureacatalysts generated the desired Michael products containing vicinal fluorinated quaternary and tertiary chiral centers with exceptional enantioselectivity.

Graphical abstract: Asymmetric generation of fluorine-containing quaternary carbons adjacent to tertiary stereocenters: uses of fluorinated methines as nucleophiles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B823184B
Article type
Communication
Submitted
24 Dec 2008
Accepted
11 Feb 2009
First published
26 Feb 2009

Chem. Commun., 2009, 2044-2046

Permissions

Request permissions

Asymmetric generation of fluorine-containing quaternary carbons adjacent to tertiary stereocenters: uses of fluorinated methines as nucleophiles

X. Han, J. Luo, C. Liu and Y. Lu, Chem. Commun., 2009, 2044 DOI: 10.1039/B823184B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements