Issue 22, 2009
From the journal:

Chemical Communications

High-resolution cross-reactive array for alkaloids†

Renjun Pei,a   Aihua Shen,a   Mark J. Olah,d   Darko Stefanovic,d   Tilla Worgallb  and  Milan N. Stojanovic*ac  

* Corresponding authors

a Division of Experimental Therapeutics, Department of Medicine, New York, USA

b Columbia University Department of Pathology, Columbia University, New York, USA

c Department of Biomedical Engineering, Columbia University, New York, USA
E-mail: mns18@columbia.edu
Fax: +1 212 305 3475

d Department of Computer Science, University of New Mexico, Albuquerque, New Mexico, USA

Abstract

A high-resolution cross-reactive array capable of classifying alkaloids over a range of concentrations was generated by systematic introduction of a nitroindole analog into a hydrophobic pocket within a DNA three-way junction to match structural motifs presented by the analytes.

Graphical abstract: High-resolution cross-reactive array for alkaloids

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Article information

DOI
https://doi.org/10.1039/B900001A
Article type
Communication
Submitted
05 Jan 2009
Accepted
01 Apr 2009
First published
01 May 2009

Chem. Commun., 2009, 3193-3195

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High-resolution cross-reactive array for alkaloids

R. Pei, A. Shen, M. J. Olah, D. Stefanovic, T. Worgall and M. N. Stojanovic, Chem. Commun., 2009, 3193 DOI: 10.1039/B900001A

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