Organocatalytic asymmetric synthesis of chiral fluorinated quaternary carbon containing β-ketoesters

Abstract

Organocatalytic enantioselective conjugate addition of α-fluoroketoesters to nitroolefins efficiently catalyzed by a cinchona alkaloid-derivative affords versatile non-enolizable ketoesters by forming two consecutive fluorinated quaternary and tertiary chiral carbon centers with excellent enantioselectivity.