Issue 4, 2010

Cu-free click cycloaddition reactions in chemical biology

Abstract

Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems—in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.

Graphical abstract: Cu-free click cycloaddition reactions in chemical biology

Article information

Article type
Tutorial Review
Submitted
08 Oct 2009
First published
19 Jan 2010

Chem. Soc. Rev., 2010,39, 1272-1279

Cu-free click cycloaddition reactions in chemical biology

J. C. Jewett and C. R. Bertozzi, Chem. Soc. Rev., 2010, 39, 1272 DOI: 10.1039/B901970G

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