Issue 19, 2009
From the journal:

Chemical Communications

Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models†

Nicole S. Bryce,‡a   Jenny Z. Zhang,‡a   Renee M. Whan,a   Natsuho Yamamotoa  and  Trevor W. Hambley*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, Australia
E-mail: t.hambley@chem.usyd.edu.au
Fax: +61-2-9351-3329
Tel: +61-2-9351-2830

Abstract

The penetration of anthraquinones and their platinum complexes into cancer cell spheroids reveals that they model well the distribution of such compounds in solid tumours and that the proportion of the compound that accumulates deep in the spheroid is inversely related to the rate of cellular uptake which is affected by the charge of the compound.

Graphical abstract: Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models

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Article information

DOI
https://doi.org/10.1039/B902415H
Article type
Communication
Submitted
04 Feb 2009
Accepted
13 Mar 2009
First published
23 Mar 2009

Chem. Commun., 2009, 2673-2675

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Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models

N. S. Bryce, J. Z. Zhang, R. M. Whan, N. Yamamoto and T. W. Hambley, Chem. Commun., 2009, 2673 DOI: 10.1039/B902415H

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