A highly selective and sensitive fluorescent turn-on sensor for Hg2+ and its application in live cell imaging

Hua Lu; Liqin Xiong; Hanzhuang Liu; Mengxiao Yu; Zhen Shen; Fuyou Li; Xiaozeng You

doi:10.1039/B902912E

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A highly selective and sensitive fluorescent turn-on sensor for Hg²⁺ and its application in live cell imaging†

Hua Lu,^a Liqin Xiong,^b Hanzhuang Liu,^a Mengxiao Yu,^b Zhen Shen,*^a Fuyou Li*^b and Xiaozeng You*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing, PR China
E-mail: zshen@nju.edu.cn, youxz@nju.edu.cn

^b Department of Chemistry & Laboratory of Advanced Materials, Fudan University, Shanghai, PR China
E-mail: fyli@fudan.edu.cn

Abstract

A boron–dipyrromethene (BODIPY) derivative containing a tridentate diaza-oxa ligand (8H-BDP) was synthesized as a fluorescent turn-on chemosensor for Hg²⁺ with high sensitivity (detection limit ≤2 ppb), a rapid response time (≤5 seconds) and specific selectivity over other cations under physiological conditions and in live cells according to the confocal fluorescence microscopy experiment.

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Article information

DOI: https://doi.org/10.1039/B902912E
Article type: Paper
Submitted: 11 Feb 2009
Accepted: 06 Apr 2009
First published: 29 Apr 2009

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Org. Biomol. Chem., 2009,7, 2554-2558

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A highly selective and sensitive fluorescent turn-on sensor for Hg²⁺ and its application in live cell imaging

H. Lu, L. Xiong, H. Liu, M. Yu, Z. Shen, F. Li and X. You, Org. Biomol. Chem., 2009, 7, 2554 DOI: 10.1039/B902912E

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Organic & Biomolecular Chemistry