Issue 13, 2009
From the journal:

Organic & Biomolecular Chemistry

Preorganized macromolecular gene delivery systems: amphiphilic β-cyclodextrin “click clusters”†

Alejandro Méndez-Ardoy,a   Marta Gómez-García,b   Carmen Ortiz Mellet,*a   Natalia Sevillano,c   M. Dolores Girón,c   Rafael Salto,*c   F. Santoyo-Gonzálezd  and  José M. García Fernández*b  

* Corresponding authors

a Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, Sevilla, Spain
E-mail: jogarcia@iiq.csic.es
Fax: +34-954460565
Tel: +34-954489559

b Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 553, Sevilla, Spain
E-mail: mellet@us.es
Fax: +34 954624960
Tel: +34 954551519

c Departamento de Bioquímica y Biología Molecular II, Facultad de Farmacia, Universidad de Granada, Granada, Spain
E-mail: rsalto@ugr.es
Fax: +34 958-248-960
Tel: +34 958246363

d Departamento de Química Orgánica, Facultad de Ciencias, Instituto de Biotecnología, Universidad de Granada, Granada, Spain

Abstract

Gene delivery systems based on the β-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling (“click chemistry”) and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the click approach.

Graphical abstract: Preorganized macromolecular gene delivery systems: amphiphilic β-cyclodextrin “click clusters”

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Article information

DOI
https://doi.org/10.1039/B903635K
Article type
Communication
Submitted
20 Feb 2009
Accepted
22 Apr 2009
First published
05 May 2009

Org. Biomol. Chem., 2009,7, 2681-2684

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Preorganized macromolecular gene delivery systems: amphiphilic β-cyclodextrin “click clusters”

A. Méndez-Ardoy, M. Gómez-García, C. O. Mellet, N. Sevillano, M. Dolores Girón, R. Salto, F. Santoyo-González and J. M. García Fernández, Org. Biomol. Chem., 2009, 7, 2681 DOI: 10.1039/B903635K

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