Issue 8, 2009

Chemistry and biology of non-tetramic γ-hydroxy-γ-lactams and γ-alkylidene-γ-lactams from natural sources

Abstract

Covering: from 1960 to 2008

Natural products containing non-tetramic γ-hydroxy-γ-lactams and γ-alkylidene-γ-lactams are usually but not exclusively derived from the mixed polyketide–non-ribosomal peptide biosynthetic pathway. Often they are fungal metabolites, although some plant- and marine-derived exceptions exist. Owing to their unique structures and biological properties, they have gained interest in the chemical and biological communities. In this review, we aim to emphasize the structural originality of these compounds, their biological properties and the synthetic efforts developed to reach them; 157 references are cited.

Graphical abstract: Chemistry and biology of non-tetramic γ-hydroxy-γ-lactams and γ-alkylidene-γ-lactams from natural sources

Article information

Article type
Review Article
Submitted
24 Feb 2009
First published
11 Jun 2009

Nat. Prod. Rep., 2009,26, 1044-1062

Chemistry and biology of non-tetramic γ-hydroxy-γ-lactams and γ-alkylidene-γ-lactams from natural sources

B. Nay, N. Riache and L. Evanno, Nat. Prod. Rep., 2009, 26, 1044 DOI: 10.1039/B903905H

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