Issue 20, 2009
From the journal:

Chemical Communications

A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase†

Li Cai,‡a   Wanyi Guan,‡ab   Motomitsu Kitaoka,c   Jie Shen,a   Chengfeng Xia,a   Wenlan Chena  and  Peng George Wang*a  

* Corresponding authors

a Departments of Chemistry and Biochemistry, The Ohio State University, 484 w. 12th Ave., Columbus, USA
E-mail: wang.892@osu.edu
Fax: +1-614-688-3106
Tel: +1-614-292-9884

b National Glycoengineering Research Center and The State Key Laboratory of Microbial Technology, Shandong University, Jinan, Shandong, People’s Republic of China

c National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki, Japan

Abstract

Reports an efficient chemoenzymatic production of an N-acetylhexosamine 1-phophate analogues library by N-acetylhexosamine 1-kinase (NahK) and describes the respective substrate specificity on this enzyme.

Graphical abstract: A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase

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Article information

DOI
https://doi.org/10.1039/B904853G
Article type
Communication
Submitted
10 Mar 2009
Accepted
31 Mar 2009
First published
24 Apr 2009

Chem. Commun., 2009, 2944-2946

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A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase

L. Cai, W. Guan, M. Kitaoka, J. Shen, C. Xia, W. Chen and P. G. Wang, Chem. Commun., 2009, 2944 DOI: 10.1039/B904853G

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