Issue 9, 2009

The topology of drug–target interaction networks: implicit dependence on drug properties and target families

Abstract

The availability of interaction data between small molecule drugs and protein targets has increased substantially in recent years. Using seven different databases, we were able to assemble a total of 4767 unique interactions between 802 drugs and 480 targets, which means that on average every drug is currently acknowledged to interact with 6 targets. The application of network theory to the analysis of these data reveals an unexpectedly complex picture of drug–target interactions. The results confirm that the topology of drug–target networks depends implicitly on data completeness, drug properties, and target families. The implications for drug discovery are discussed.

Graphical abstract: The topology of drug–target interaction networks: implicit dependence on drug properties and target families

Supplementary files

Article information

Article type
Paper
Submitted
23 Mar 2009
Accepted
26 May 2009
First published
08 Jul 2009

Mol. BioSyst., 2009,5, 1051-1057

The topology of drug–target interaction networks: implicit dependence on drug properties and target families

J. Mestres, E. Gregori-Puigjané, S. Valverde and R. V. Solé, Mol. BioSyst., 2009, 5, 1051 DOI: 10.1039/B905821B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements