Issue 15, 2009

The catalyticortho-arylation of tyrosine

Abstract

The rhodium-catalysed direct ortho-arylation of protected racemic 2-tert-butyl tyrosine has been developed. The subsequent removal of the tert-butyl group yields the 2-arylated tyrosine which can undergo further rhodium-based arylation at the 6-position. In one instance a product formed by further arylation of the diarylated species was isolated.

Graphical abstract: The catalyticortho-arylation of tyrosine

Supplementary files

Article information

Article type
Paper
Submitted
27 Mar 2009
Accepted
21 May 2009
First published
15 Jun 2009

Org. Biomol. Chem., 2009,7, 3119-3127

The catalyticortho-arylation of tyrosine

R. B. Bedford, M. F. Haddow, R. L. Webster and C. J. Mitchell, Org. Biomol. Chem., 2009, 7, 3119 DOI: 10.1039/B906119C

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