Issue 21, 2009

Dynamic patterns in a supported lipid bilayer driven by standing surface acoustic waves

Abstract

In the past decades supported lipid bilayers (SLBs) have been an important tool in order to study the physical properties of biological membranes and cells. So far, controlled manipulation of SLBs is very limited. Here we present a new technology to create lateral patterns in lipid membranes controllable in both space and time. Surface acoustic waves (SAWs) are used to generate lateral standing waves on a piezoelectric substrate which create local “traps” in the lipid bilayer and lead to a lateral modulation in lipid concentration. We demonstrate that pattern formation is reversible and does not affect the integrity of the lipid bilayer as shown by extracting the diffusion constant of fluid membranes. The described method could possibly be used to design switchable interfaces for the lateral transport and organization of membrane bound macromolecules to create dynamic bioarrays and control biofilm formation.

Graphical abstract: Dynamic patterns in a supported lipid bilayer driven by standing surface acoustic waves

Supplementary files

Article information

Article type
Method
Submitted
08 Apr 2009
Accepted
29 Jun 2009
First published
30 Jul 2009

Lab Chip, 2009,9, 3050-3053

Dynamic patterns in a supported lipid bilayer driven by standing surface acoustic waves

M. Hennig, J. Neumann, A. Wixforth, J. O. Rädler and M. F. Schneider, Lab Chip, 2009, 9, 3050 DOI: 10.1039/B907157A

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