Issue 9, 2010
From the journal:

Chemical Communications

Ionic liquid-assisted transdermal delivery of sparingly soluble drugs†

Muhammad Moniruzzaman,a   Yoshiro Tahara,a   Miki Tamura,a   Noriho Kamiyaab  and  Masahiro Goto*ab  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka, Fukuoka 819-0395, Japan

b Center for Future Chemistry, Kyushu University, 744 Moto-oka, Fukuoka 819-0395, Japan
E-mail: m-goto@mail.cstm.kyushu-u.ac.jp
Fax: (+81)92-802-2810
Tel: (+81)92-802-2806

Abstract

We report the first successful application of a novel IL-assisted non-aqueous microemulsion stabilized by a blend of two nontoxic surfactants, polyoxyethylene sorbitan monooleate (Tween-80), and sorbitan laurate (Span-20) for transdermal delivery of acyclovir, which is insoluble or sparingly soluble in water and most common organic liquids.

Graphical abstract: Ionic liquid-assisted transdermal delivery of sparingly soluble drugs

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Article information

DOI
https://doi.org/10.1039/B907462G
Article type
Communication
Submitted
15 Apr 2009
Accepted
25 Nov 2009
First published
14 Jan 2010

Chem. Commun., 2010,46, 1452-1454

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Ionic liquid-assisted transdermal delivery of sparingly soluble drugs

M. Moniruzzaman, Y. Tahara, M. Tamura, N. Kamiya and M. Goto, Chem. Commun., 2010, 46, 1452 DOI: 10.1039/B907462G

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