Issue 36, 2009

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

Abstract

Aberrant glycosylation of glycoproteins and glycolipids of cancer cells, which correlates with poor survival rates, is being exploited for the development of immunotherapies for cancer. In particular, advances in the knowledge of cooperation between the innate and adaptive system combined with the implementation of efficient synthetic methods for assembly of oligosaccharides and glycopeptides is providing avenues for the rationale design of vaccine candidates. In this respect, fully synthetic vaccine candidates show great promise because they incorporate only those elements requires for relevant immune responses, and hence do not suffer from immune suppression observed with classical carbohydrate–protein conjugate vaccines. Such vaccines are chemically well-defined and it is to be expected that they can be produced in a reproducible fashion. In this feature article, recent advances in the development of fully synthetic sub-unit carbohydrate-based cancer vaccines will be discussed.

Graphical abstract: Immunotherapy for cancer: synthetic carbohydrate-based vaccines

Article information

Article type
Feature Article
Submitted
30 Apr 2009
Accepted
08 Jun 2009
First published
22 Jul 2009

Chem. Commun., 2009, 5335-5349

Immunotherapy for cancer: synthetic carbohydrate-based vaccines

T. Buskas, P. Thompson and G. Boons, Chem. Commun., 2009, 5335 DOI: 10.1039/B908664C

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