Issue 29, 2009

The organocatalytic addition of bis(arylsulfonyl)methane to α,β-unsaturated aldehydes and the synthesis of optically-enriched 3-methyl-alkanols

Abstract

An indirect organocatalytic method for the β-methylation of α,β-unsaturated aldehydes that involves the addition of bis(arylsulfonyl)methane catalyzed by prolinol derivatives and further elimination of the chameleonic sulfonyl groups is presented.

Graphical abstract: The organocatalytic addition of bis(arylsulfonyl)methane to α,β-unsaturated aldehydes and the synthesis of optically-enriched 3-methyl-alkanols

Supplementary files

Article information

Article type
Communication
Submitted
06 May 2009
Accepted
22 May 2009
First published
12 Jun 2009

Chem. Commun., 2009, 4435-4437

The organocatalytic addition of bis(arylsulfonyl)methane to α,β-unsaturated aldehydes and the synthesis of optically-enriched 3-methyl-alkanols

J. L. García Ruano, V. Marcos and J. Alemán, Chem. Commun., 2009, 4435 DOI: 10.1039/B908963B

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