Issue 35, 2009
From the journal:

Chemical Communications

Fluoride protects boronic acids in the copper(i)-mediated click reaction†

Shan Jin,a   Gaurav Choudhary,a   Yunfeng Cheng,a   Chaofeng Dai,a   Minyong Li*ab  and  Binghe Wang*a  

* Corresponding authors

a Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, USA
E-mail: wang@gsu.edu
Fax: +1 404-413-5543
Tel: +1 404-413-5544

b Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China
E-mail: mli@sdu.edu.cn
Fax: +86 531-8838-2076
Tel: +86 531-8838-2076

Abstract

Fluoride has been found to protect boronic acids from copper(I)-mediated decomposition; such findings should be very useful for the preparation of boronic acid-based carbohydrate sensors and boronic acid conjugates using the copper(I)-mediated click reaction.

Graphical abstract: Fluoride protects boronic acids in the copper(i)-mediated click reaction

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Article information

DOI
https://doi.org/10.1039/B909575F
Article type
Communication
Submitted
14 May 2009
Accepted
30 Jun 2009
First published
06 Aug 2009

Chem. Commun., 2009, 5251-5253

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Fluoride protects boronic acids in the copper(I)-mediated click reaction

S. Jin, G. Choudhary, Y. Cheng, C. Dai, M. Li and B. Wang, Chem. Commun., 2009, 5251 DOI: 10.1039/B909575F

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