Palladium-catalysed synthesis of 1-isoindolecarboxylic acidesters and sequential Diels–Alder reactions: access to bridged- and fused-ring heterocycles

Abstract

The Pd-catalysed intramolecular α-arylation of α-amino acid esters provides a useful methodology for the synthesis of substituted isoindole derivatives, which have been used in Diels–Alder reactions to access diverse skeletal frameworks.