Issue 32, 2009

New catalytic properties of iron complexes: dehydration of amides to nitriles

Abstract

Various iron carbonyl clusters such as Fe2(CO)9 or [Et3NH][HFe3(CO)11] are shown to catalyze the dehydration of amides into the corresponding nitriles in the presence of silanes in high yields; this novel protocol showed good functional group tolerance and wide substrate scope.

Graphical abstract: New catalytic properties of iron complexes: dehydration of amides to nitriles

Supplementary files

Article information

Article type
Communication
Submitted
22 May 2009
Accepted
25 Jun 2009
First published
13 Jul 2009

Chem. Commun., 2009, 4883-4885

New catalytic properties of iron complexes: dehydration of amides to nitriles

S. Zhou, D. Addis, S. Das, K. Junge and M. Beller, Chem. Commun., 2009, 4883 DOI: 10.1039/B910145D

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