Issue 39, 2009
From the journal:

Chemical Communications

A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6†

Tae-Il Kim,‡a   Hyo Jin Kang,‡b   Garam Han,a   Sang J. Chung*b  and  Youngmi Kim*a  

* Corresponding authors

a Department of Chemistry, Dankook University, 126 Jukjeon-dong, Yongin-si, Gyeonggi-do, Korea
E-mail: youngmi@dankook.ac.kr
Fax: +82 31-8005-3148
Tel: +82 31-8005-3156

b BioNanotechnology Research Center, KRIBB, and Nanobio Division, UST, 52 Eoeun-dongYuseong, Daejeon 305-333, Korea
E-mail: sjchung@kribb.re.kr
Fax: +82 42-879-8594
Tel: +82 42-879-8433

Abstract

A highly selective fluorescent probe for a protein tyrosine phosphatase (PTP) was designed by a simple phosphorylation of the 2-(2′-hydroxyphenyl)benzothiazole (HBT) chromophore: upon selective enzymatic hydrolysis, an excited-state intramolecular proton transfer (ESIPT) occurs, resulting in a large Stokes shift.

Graphical abstract: A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6

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Article information

DOI
https://doi.org/10.1039/B911145J
Article type
Communication
Submitted
08 Jun 2009
Accepted
24 Jul 2009
First published
17 Aug 2009

Chem. Commun., 2009, 5895-5897

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A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6

T. Kim, H. J. Kang, G. Han, S. J. Chung and Y. Kim, Chem. Commun., 2009, 5895 DOI: 10.1039/B911145J

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