Issue 8, 2010

4-Hydroxy-2-pyridone alkaloids: Structures and synthetic approaches

Abstract

Covering: 1982 to 2009

4-Hydroxy-2-pyridone alkaloids exert diverse biological effects, ranging from antifungal, antibacterial, insecticidal and cytotoxic activity to the induction of neurite outgrowth in different cell assays. For this reason, this class of compounds has attracted much attention in the scientific community, resulting in the elucidation of the biosynthesis of some members which are formed by fungal polyketide synthases via tetramic acids by fungal polyketide synthases as well as different total synthesis approaches. This article will give a summary of the so far known structures, overview the different activities of the compounds and disclose the synthetic attempts since 1982.

Graphical abstract: 4-Hydroxy-2-pyridone alkaloids: Structures and synthetic approaches

  • This article is part of the themed collection: Synthesis

Article information

Article type
Review Article
Submitted
24 Mar 2010
First published
08 Jun 2010

Nat. Prod. Rep., 2010,27, 1168-1185

4-Hydroxy-2-pyridone alkaloids: Structures and synthetic approaches

H. J. Jessen and K. Gademann, Nat. Prod. Rep., 2010, 27, 1168 DOI: 10.1039/B911516C

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