Issue 4, 2010
From the journal:

Natural Product Reports

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

Carlos Olano,a   Carmen Méndeza  and  José A. Salas*a  

* Corresponding authors

a Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, Oviedo, Spain
E-mail: jasalas@uniovi.es
Fax: +34-985-103652
Tel: +34-985-103652

Abstract

Covering: 2002 to September 2009

In recent years, a number of gene clusters involved in the biosynthesis of polyketide compounds have been characterized and the genes have been used for designing and developing novel chemical entities by combinatorial biosynthesis. This review covers the highlights of combinatorial biosynthesis using polyketide-modifying enzymes such as oxidoreductases, group transferases, halogenases, cyclases and deoxysugar biosynthesis enzymes, focusing on those from actinomycetes (with 315 references cited).

Graphical abstract: Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

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Article information

DOI
https://doi.org/10.1039/B911956F
Article type
Review Article
Submitted
15 Dec 2009
First published
25 Feb 2010

Nat. Prod. Rep., 2010,27, 571-616

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Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

C. Olano, C. Méndez and J. A. Salas, Nat. Prod. Rep., 2010, 27, 571 DOI: 10.1039/B911956F

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